111 articles - From Saturday Apr 23 2022 to Friday Apr 29 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Circulating bile acid concentrations and non-alcoholic fatty liver disease in Guatemala. GCA, TCA) and the secondary bile acids that derive from CA (i. e. DCA, TDCA) may indicate there is hepatic overproduction of CA, which may affect the liver via aberrant signalling mediated by the bile acids. |
Early predictors of corticosteroid response in acute severe autoimmune hepatitis: A nationwide multicenter study. Older patients with high MELD, encephalopathy or ascites at steroid therapy initiation and during treatment are unlikely to show a favourable response and so prolonged therapy in these patients, especially if they are transplantation candidates, should be avoided. |
Longitudinal monitoring of STAT3 phosphorylation and histologic outcome of tofacitinib therapy in patients with ulcerative colitis. However, lamina propria pSTAT3 was significantly associated with the Nancy Histologic index (p = 0.004). Tofacitinib can induce and maintain endoscopic and histologic remission in up to one-quarter of highly refractory UC patients. Longitudinal monitoring of nuclear pSTAT3 in mucosal tissue compartments reflects distinctive on-target effects, independently of long-term treatment outcomes. |
Real-world data on switching from intravenous to subcutaneous vedolizumab treatment in patients with inflammatory bowel disease. The switch from intravenous to subcutaneous vedolizumab could be done with preserved therapeutic effectiveness, safety, high patient satisfaction and low discontinuation rate, at a reduced cost. |
Real-world multicentre observational study including population pharmacokinetic modelling to evaluate the exposure-response relationship of vedolizumab in inflammatory bowel disease: ERELATE Study. In this real-world study, a positive exposure-response relationship was observed for vedolizumab. Vedolizumab concentration during induction may be an important predictor of short- and long-term outcomes, and similarly, vedolizumab baseline clearance may be an important predictor of remission. |
The risk of unexpected hospital admissions and primary care visits after an elective day-case gastroscopy: A cohort study within England. There was an excess of vascular and respiratory events associated with a diagnostic gastroscopy. In younger patients, this risk manifested as an increase in primary care consultations while in older patients there was an increase in emergency hospital admissions. |
| Am J Gastroenterol |
Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer. Germline pathogenic variants in the PTEN gene cause overlapping clinical phenotypes (known as the PTEN hamartoma tumor syndromes), including Cowden's syndrome and related disorders that are associated with an increased risk of gastrointestinal and colonic polyposis, colon cancer, and other extraintestinal manifestations and cancers. Due to the relative rarity of the hamartomatous polyposis syndromes, recommendations for management are based on few studies. This US Multi-Society Task Force on Colorectal Cancer consensus statement summarizes the clinical features, assesses the current literature, and provides guidance for diagnosis, assessment, and management of patients with the hamartomatous polyposis syndromes, with a focus on endoscopic management. |
Objective comparison of vedolizumab and ustekinumab effectiveness in Crohn's disease patients failure to TNF-alpha inhibitors. In CD patients in which TNFi failed, both ustekinumab and vedolizumab showed similar clinical effectiveness after 26 weeks of treatment. At one-year vedolizumab was associated with higher rate of clinical remission as compared to ustekinumab. Thought, no difference was observed between the two groups when objective outcomes were investigated at this time point. |
Overweight and obese status is not associated with disease activity for children and adolescents with newly diagnosed IBD. Obese and overweight children with newly diagnosed IBD do not appear to have worsened disease activity at 1 year after diagnosis compared to normal weight children. |
| Clin Gastroenterol Hepatol |
| Endoscopy |
Endoscopic sigmoidopexy for recurrent sigmoid volvulus in inoperable patients: a retrospective series on 15 patients. PES using Chait catheters offers an effective and feasible approach for recurrent sigmoid volvulus treatment and should be considered as an alternative option to sigmoidectomy in inoperable patients. |
Motorized Spiral Enteroscopy: Results of an international, multicenter, prospective observational clinical study on patients with normal and altered gastrointestinal anatomy. This prospective multicenter study showed that MSE was feasible and safe in a large cohort of patients in a real-life setting after a short learning curve. MSE was shown to be feasible in postsurgical patients and patients with altered anatomy without AE rate increase. NCT03955081 (clinicaltrials.gov). |
PREDICTORS OF ADVERSE EVENTS AFTER ENDOSCOPIC ULTRASOUND THROUGH-THE-NEEDLE BIOPSY OF PANCREATIC CYSTS: A RECURSIVE PARTITIONING ANALYSIS. TTNB should be selectively used in the evaluation of patients with IPMN. The present model could be applied during patient selection as to optimize the benefit/risk of TTNB. |
Self-expandable duodenal metal stent placement for palliation of gastric outlet obstruction over the past 20 years. Prior treatment with chemotherapy and/or radiotherapy was significantly associated with an increased risk of adverse events (OR 2.53, P=0.02). Clinical outcome of duodenal stent placement did not improve over time. The decreased GOO-symptom free survival and increased adverse event rate in more recent years are probably related to the chemo- and/or radiotherapy treatment provided prior to duodenal stent placement. |
| Gastroenterology |
Estrogen-Related Receptor Collectively, our findings highlight an essential role for ERR |
Factors Associated with Geographic Disparities in Gastrointestinal Cancer Mortality in the United States. Cigarette smoking and rural residence (independent of specialist density) were most strongly associated with GI cancer-related mortality. Both patient and structural factors contribute to significant geographic differences in mortality from GI cancers. Our findings support continued public health efforts to reduce smoking use and improve care for rural patients, which may contribute to a reduction in disparities in GI cancer-related death. |
Loss of Arid1a and Pten in pancreatic ductal cells induces intraductal tubulopapillary neoplasm via the YAP/TAZ pathway. Furthermore, pharmacological inhibition of the YAP/TAZ pathway suppressed the dedifferentiation of pancreatic ductal cells and development of ITPN in Arid1a and Pten double knockout mice. Concurrent loss of Arid1a and Pten in adult pancreatic ductal cells induced ITPN and ITPN-derived PDAC in mice through aberrant activation of YAP/TAZ pathway, and inhibition of YAP/TAZ pathway prevented the development of ITPN. These findings provide novel insights into the pathogenesis of ITPN-derived PDAC and highlight the YAP/TAZ pathway as a potential therapeutic target. |
| Gastrointest Endosc |
Clinical benefit of tunnel endoscopic submucosal dissection for esophageal squamous cancer: a multicenter, randomized controlled trial. Our study suggests that tunnel ESD results in shorter procedure time, specifically for lesions = 1/2 circumference of the esophagus. Besides, T-ESD has a better safety profile indicated by less frequent muscular injury and improved healing of artificial mucosal defects caused by ESD procedures. |
Efficacy of narrow-band imaging during peroral cholangioscopy for predicting malignancy of indeterminate biliary strictures (with videos). Direct POC under NBI effectively and accurately predicts malignancies of indeterminate biliary strictures; NBI well-illuminates the surface structures, microvessels, and lesional margins. |
Pre-Endoscopy COVID-19 screening and SARS-CoV-2 nucleic acid amplification testing in the VA Healthcare System: Clinical practice patterns, outcomes, and relationship to procedure volume. These findings have important implications for decisions about pre-procedure testing, especially given breakthrough infections among vaccinated individuals during the SARS-CoV-2 delta and omicron variant surge. |
Predicting success of direct endoscopic necrosectomy with lumen-apposing metal stents for pancreatic walled-off necrosis. Paracolic gutter extension, increasing APACHE-II score and greater than 50% gland necrosis are negative predictors for success of DEN with LAMS in WON. This prediction model with nomogram may be helpful in clinical decision making and prognostication. |
| Gut |
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. This study reveals new biological insight that offers a novel therapeutic option to reduce relapse rates in patients with the worst prognosis CC. |
Diet or medication in primary care patients with IBS: the DOMINO study - a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute. In primary care IBS patients, a FODMAP-lowering diet application was superior to a spasmolytic agent in improving IBS symptoms. A FODMAP-lowering diet should be considered the first-line treatment for IBS in primary care. NCT04270487. |
Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial. In severe gastroparesis, G-POEM is superior to a sham procedure for improving both symptoms and gastric emptying 6 months after the procedure. These results are not entirely conclusive in patients with idiopathic and postsurgical aetiologies. |
| Hepatology |
Intestinal Peroxisome Proliferator-Activated Receptor a-Fatty Acid Binding Protein 1 Axis Modulates Nonalcoholic Steatohepatitis. Intestinal PPARa signaling promotes NASH progression via regulating dietary fatty acid uptake through modulation of FABP1, which provides a compelling therapeutic target for NASH treatment. |
The steatosis-associated fibrosis estimator (SAFE) score: A tool to detect low-risk non-alcoholic fatty liver disease in primary care. The SAFE score, which uses widely available variables to estimate liver fibrosis in patients diagnosed with NAFLD, may be used in primary care to recognize low-risk NAFLD. |
| Inflamm Bowel Dis |
Efficacy of Hepatitis B Vaccination with a Novel Immunostimulatory Sequence Adjuvant (Heplisav-B) in Patients With Inflammatory Bowel Disease. Heplisav-B, a 2-dose vaccine, is an effective vaccine for HBV in patients with IBD. In our study, its overall efficacy (78.3%) is greater than that reported for the presently available 3-dose vaccination (Engerix) in patients with IBD. |
Increased Risk of Postpartum Infections After Caesarian and Vaginal Delivery in Women With Inflammatory Bowel Disease: A Danish Nationwide Cohort Study. The risk of a 30-day postpartum infectious complication is increased in women with IBD. Physicians should carefully monitor their patients postpartum to prevent these adverse outcomes. |
Use and Misuse of Parenteral Nutrition in Patients with Inflammatory Bowel Disease. Appropriate use of PN is critical in order to prevent associated complications. This review addresses the common indications for use of PN, the composition of PN, and the possible complications encountered with PN use, as well as scenarios of inappropriate PN use among patients with IBD. A clinical management algorithm for utilizing PN among patients with IBD is proposed in this review. |
| J Crohns Colitis |
Diagnostic performance of magnetic resonance enterography disease activity indices compared with a histological reference standard for adult terminal ileal Crohn's disease: experience from the METRIC trial. When tested at their proposed cut-offs in a real-world setting, sMARIA, London and "extended" London indices achieve high sensitivity for active TI disease against a histological reference standard, but specificity is low. |
| J Hepatol |
A randomized-controlled trial comparing 20% albumin to plasmalyte in patients with cirrhosis and sepsis-induced hypotension [ALPS trial]. In patients with cirrhosis and SIH, 20% albumin transiently improves the hemodynamics with early lactate clearance than plasmalyte but needs monitoring as it is more often attended with pulmonary complications. Both fluids provide comparable 28 days survival. NCT02721238 |
A third dose of the BNT162b2 mRNA vaccine significantly improves immune responses among liver transplant recipients. After a third BNT162b2 mRNA vaccine, the immune response improved significantly among LT recipients, without serious adverse effects. Further studies are needed to evaluate immune response durability and determine the optimal number and schedule of boost vaccines. |
Efficacy and safety of vebicorvir administered in virologically-suppressed patients with chronic hepatitis B virus infection. In this 24-week study, VBR+NrtI demonstrated a favourable safety and tolerability profile. While there were no significant changes in viral antigen levels, enhanced viral suppression was evident by greater changes in DNA and pgRNA with the addition of VBR compared to NrtI alone. |
Feasibility of hepatitis B elimination in high-income countries with ongoing immigration. We have developed an agent-based model that reflects the dynamics of HBV transmission in a high-income country region that with ongoing immigration, which enables forecasting the epidemiology of HBV for policy-level decision making. Our analysis suggests that current vaccination, screening, and treatment strategies are inadequate to achieve the WHO goals of eliminating chronic hepatitis B. Even with extensive integrated scale-up in vaccination, screening, and treatment, the morbidity and mortality targets may not be reachable. |
SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis. COVID19 vaccination can elicit a distinct T cell-dominant immune-mediated hepatitis with a unique pathomechanism associated with vaccination induced antigen-specific tissue-resident immunity requiring systemic immunosuppression. |
Structured Early detection of Asymptomatic Liver Cirrhosis: Results of the population-based liver screening program SEAL. The implementation of a structured screening program may increase the early detection rate of cirrhosis in the general population. In this context, the SEAL pathway represents as a feasible and potentially cost-effective screening program. Registration DRKS00013460 |
| Neurogastroenterol Motil |
Alterations in brain activation patterns in women with functional defecatory disorder: A novel fMRI rectal balloon expulsion study. Our results provide evidence that distinct differences exist in supra-spinal control of defecation in key regions of motivational-affective regulation and executive-cognitive function, in patients with FDD as compared to controls. |
Fasting pyloric diameter and distensibility by functional endoluminal imaging probe in unsedated healthy volunteers. Unsedated EndoFLIP ® can be used to characterize human fasting pyloric diameter and distensibility, with best performance observed with 40 ml and 50 ml distensions and data collection during the second minute. Normative values reported serve as reference values for future studies. |
The visceral sensitivity index: A novel tool for measuring GI-symptom-specific anxiety in inflammatory bowel disease. Our findings suggest the VSI is a useful measure in IBD. The VSI in IBD is related to general anxiety but is measuring a different construct and is not affected by the presence of trait anxiety. IBD patients have GSA that is associated with decreased HRQOL, which can negatively affect treatment compliance and other long-term disease outcomes. Future studies are needed to further validate the VSI in IBD and to assess its correlation with disease activity. |
Transcutaneous vagal nerve stimulation protects against stress-induced intestinal barrier dysfunction in healthy adults. Brief non-invasive vagal nerve stimulation consistently reduces paracellular permeability of the small intestine after CRH administration, but does not entirely mitigate I-FABP release from the epithelium. Studies of vagal nerve stimulation in disease states are warranted. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
Review article: rethinking the "ladder" approach to reflux-like symptom management in the era of PPI "resistance": a multidisciplinary perspective. Management of reflux-like symptoms should be adapted to reflect the advances in knowledge about the multifactorial aetiology of these symptoms, addressing both acid-related and behavioural components early in management. The time has come to treat the patient, not the "disease". |
| Gastrointest Endosc |
| Gut |
Recent advances in clinical practice: management of inflammatory bowel disease during the COVID-19 pandemic. Reassuringly, rates of breakthrough infections and hospitalisations in al patients who received vaccines, irrespective of IBD treatment, remained low. International guidelines recommend that al patients with IBD treated with immunosuppressive therapies should receive, at any point during their treatment cycle, three primary doses of SARS-CoV-2 vaccines with a further booster dose as soon as possible. Future research should focus on our understanding of the rate of antibody decay in biological-treated patients, which patients require additional doses of SARS-CoV-2 vaccine, the long-term risks of COVID-19 on IBD disease course and activity, and the potential risk of long COVID-19 in patients with IBD. |
| Hepatology |
NAFLD-related hepatocellular carcinoma: The growing challenge. However, the occurrence of NAFLD-related HCC in patients without cirrhosis is increasingly recognized and poses a significant challenge regarding cancer surveillance. It is of paramount importance to develop optimal risk stratification scores and models to identify subsets of the population at high risk so they can be enrolled in surveillance programs. In this review, we will discuss the risks and prediction models for NAFLD-related HCC. |
Tip of the iceberg: A comprehensive review of liver disease in Inborn errors of immunity. Awareness of these hepatobiliary diseases has lagged the improved management of the underlying disorders, leading to missed opportunities to improve clinical outcomes. This review article provides a detailed description of specific liver diseases occurring in various inborn errors of immunity. A generalized approach to diagnosis and management of hepatic complications is provided and collaboration with hepatologists, immunologists, and pathologists is emphasized as a requirement for optimizing management and outcomes. |
| Inflamm Bowel Dis |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| Inflamm Bowel Dis |
| J Hepatol |
| Neurogastroenterol Motil |
all remaining publications eg case reports, images of the month, etc…
| Am J Gastroenterol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| Inflamm Bowel Dis |